This article summarizes the multidisciplinary integrated nursing experience for 4 patients with polytrauma and spinal cord injury due to falls from great heights.The nursing care included:establishing a "1+1" collaborative emergency response model; implementing precise assessment and intervention based on the injury mechanism; applying graded immobilization and skin protection during the critical phase; adopting stepped anticoagulation therapy to balance bleeding and thrombosis risks; and conducting graded psychological interventions to prevent acute stress disorder.None of the 4 patients developed complications such as secondary nerve injury or pressure injuries.Ultimately, 2 patients recovered and were discharged, while the other 2 were transferred to the rehabilitation department for continued treatment.