Objective To investigate the effects of a nurse-led remote follow-up program in bladder cancer patients with urostomy. Methods A total of 150 bladder cancer patients who underwent ileostomy surgery were randomly assigned to either a control group or an intervention group, with 75 in each group.The control group received routine discharge education and telephone follow-up, while their counterparts in the intervention group received a 6-month nurse-led remote follow-up intervention program.The stoma self-efficacy, stoma quality of life (QOL), and incidence of stoma related complications were compared between the two groups. Results A total of 72 patients in the control group and 73 in the intervention group completed the study.The intervention group demonstrated significantly higher stoma self-efficacy and stoma-QOL scores, and significantly lower incidence of stoma-related complications compared to the control group (all P＜0.05). Conclusion Nurse-led remote follow-up program can effectively enhance stoma self-efficacy and quality of life, and reduce complications in bladder cancer patients with urostomy.