Objective To examine the reliability, validity, and cross-gender measurement equivalence of the Family Emotional Labor Scale for Parent-Child Interaction (FELS-PC) among parents of children with autism spectrum disorder (ASD). Methods A cross-sectional survey was conducted among 369 parents of ASD children using a general information questionnaire and the FELS-PC. The reliability, validity, and cross-gender measurement equivalence of the scale were tested. Results The FELS-PC consists of 14 items across four dimensions: surface acting (6 items), deep acting (3 items), expression of naturally felt emotions (3 items), and emotional termination (2 items).The item-level content validity index (I-CVI) ranged from 0.889 to 1.000, and the average scale-level content validity index (S-CVI/Ave) was 0.968. Confirmatory factor analysis showed good model fit indices (χ2/df=2.270, RMSEA=0.059, NFI=0.952, CFI=0.973, TLI=0.965). The Average Variance Extracted (AVE) for each dimension ranged from 0.657 to 0.733, with composite reliability (CR) values ranging from 0.846 to 0.933. The square root of the AVE for each dimension ranged from 0.810 to 0.856, indicating acceptable discriminant validity. The Cronbach′s αcoefficient for the full scale was 0.893, and the split-half reliability coefficient was 0.939. Multi-group confirmatory factor analysis indicated that the FELS-PC exhibited cross-gender measurement equivalence. Conclusion The FELS-PC demonstrates good reliability, validity, and cross-gender measurement equivalence, and can be used to assess the emotional labor of parents of ASD children in parent-child interaction scenarios.