Objective To investigate the current status of perceived nursing presence among breast cancer patients undergoing posto-perative chemotherapy and to analyze its influencing factors. Methods A survey was conducted among 277 hospitalized patients undergoing postoperative chemotherapy for breast cancer using a general information questionnaire, the Nursing Presence Scale for Hospitalized Patients, the Nurse-Patient Trust Scale, the Caring Behaviour Inventory (CBI), the Hospital Anxiety and Depression Scale (HADS), and the Eysenck Personality Questionnaire-Revised Short Form (EPQ-RS). Results The total score for perceived nursing presence among these patients was 133.00 (125.00, 144.00). Multiple linear regression analysis showed that recurrence or metastasis, nurse-patient trust, and nurse caring behaviors were significant influencing factors of perceived nursing presence among patients (all P<0.05).Conclusion Perceived nursing presence in breast cancer patients undergoing postoperative chemotherapy is at a relatively high level. Factors such as recurrence/metastasis status, nurse-patient trust, and nurse caring behaviors significantly influence this perception. Nursing staff should pay close attention to the perceived nursing presence of patients with recurrence or metastasis, establish a strong relationship of mutual trust, and integrate the philosophy of humanistic care into nursing practice to enhance patients′ perception of caring behaviors.