Objective To develop a non-pharmacological intervention program for community-dwelling women with bone and joint pain associated with perimenopausal syndrome, and to evaluate its application effects. Methods A preliminary non-pharmacological intervention program for community-dwelling women with bone and joint pain associated with perimenopausal syndrome was deve-loped based on the JBI evidence-based framework, which was then reviewed and revised by experts, and followed by localized refinement and adaptation according to the FAME principles, finally a scientific and feasible intervention program was formed.A total of 76 community-dwelling women with bone and joint pain associated with perimenopausal syndrome were recruited and divided into a control group and an experimental group chronologically, with 38 women in each group.The control group received routine care, while the experimental group received additional care according to the non-pharmacological intervention program for two months. Results Thirty-five women in each group completed the study.After the intervention, the scores of pain and the Menopause-specific Quality of Life Questionnaire in the experimental group were significantly lower than those of the control group (all P＜0.05). Conclusion The evidence-based non-pharmacological intervention program is conducive to alleviating pain for community-dwelling women with bone and joint pain associated with perimenopausal syndrome, and improving their quality of life during perimenopausal period.