Objective To develop a cognitive impairment management platform for patients with pituitary adenoma, and to evaluate its usability, so as to provide a reference for the management of cognitive impairment in this population. Methods Based on the theory of ecological momentary assessment and intervention and integrated with artificial neural network technology, a cognitive impairment management platform for patients with pituitary adenoma was developed.Using purposive sampling, 10 patients and 12 healthcare professionals were recruited for preliminary platform testing and semi-structured interviews, and the platform was optimized based on their feedback.Subsequently, 76 patients and 72 healthcare professionals were recruited by convenience sampling to use the optimized platform, and its usability was evaluated. Results There were no statistically significant differences between patients and healthcare professionals in the scores of all dimensions and the overall rating of the Post-Study System Usability Questionnaire (all P＞0.05), and all scores were more than 4.0. Conclusion The platform demonstrates good usability and may serve as a tool for remote cognitive support and training for patients with pituitary adenoma.