Objective To explore the current status of constructive deviance among clinical nurses, and to analyze its latent profile characteristics and influencing factors. Methods A total of 715 clinical nurses from four tertiary grade A hospitals in Shandong Pro-vince were selected by convenience sampling, then they were investigated by using a general information questionnaire, the Constructive Deviant Behavior Scale, the Felt Responsibility for Constructive Change Scale, the Multifactor Leadership Questionnaire, and the Perceived Organizational Support Scale.Latent profile analysis was performed to analyze constructive deviance, and univa-riate and logistic regression analyses were conducted to identify its influencing factors. Results The participants′ score of constructive deviance was (28.66±9.10). Three latent profiles were identified:conservative compliance type (23.36%), situational trade-off type (44.90%), and proactive type (31.75%).Logistic regression analysis showed that, educational background, monthly income, managerial position, preference for nursing work, perceived responsibility, perceived organizational support, and transformational leadership style were influencing factors of constructive deviance among clinical nurses （all P＜0.05）. Conclusion The level of constructive deviance among clinical nurses is low to moderate with heterogeneity. Nursing managers can implement classified management based on the influencing factors of different latent profiles, so as to enhance the level of constructive deviance among clinical nurses.