Objective To construct an early activity management information system for ICU patients, and to provide a reference for its application in ICU patients. Methods Based on the previously developed early mobilization program, an early activity management information system for ICU patients was developed. Five major modules were available for the platform:risk assessment, activity implementation, safety warning, effect evaluation, and data statistics. A prospective quasi-experimental design was adopted. Patients included before the system was applied were assigned to the control group (87 cases), and those included after the system was applied were assigned to the intervention group (86 cases). The control group underwent early mobilization using a paper-based early mobilization protocol, whereas the intervention group utilized an early mobilization management system. Results In the intervention group, the initial risk assessment time was (11.3±3.2) hours, with a mobilization implementation rate of 55.8%. The activity-related adverse event rate was 0.23%, and the activity level score was 4 (3, 7). These indicators were significantly superior to the control group (P < 0.05 for all comparisons). The overall satisfaction score of healthcare personnel with the system was (104.28±2.10) points. Conclusion The early activity management information system for ICU patients has good scientific nature and user satisfaction. It realizes the full closed-loop management from risk assessment to activity implementation, monitoring, warning, and effect evaluation of early activities, thereby improving the implementation effect and ensuring patient safety.