Objective To develop an intelligent management system for reusable emergency medical devices and explore its application effectiveness in the management of such devices. Methods By designing an intelligent management system for emergency reusable medical devices and applying it in clinical practice, an intelligent management system for emergency reusable devices was developed through hardware design of the management cabinet and the embedding of software such as the touch control management system, facial recognition system, card swipe recognition system, distributed control system (DCS), and Radio Frequency Identification (RFID) system. Using the system implementation time as the cutoff point, 2,103 emergency reusable devices under the traditional management model from June to November 2023 were designated as the pre-application group, while 1,477 emergency reusable devices under the intelligent management model from December 2023 to May 2024 were designated as the post-application group. The application effects of the intelligent management system in the management of reusable devices were analyzed. Results After the implementation of the intelligent management system for reusable emergency medical devices, the timely recovery rate of reusable devices increased, the loss rate decreased, and healthcare staff satisfaction improved compared to the pre-application period. The differences were statistically significant (P<0.05). Conclusion The design and application of the intelligent management system for emergency reusable medical devices have enabled comprehensive intelligent management of the entire process, thereby improving the circulation efficiency of these devices.