Objective To develop and evaluate the usability of a personalized information recommendation system for the home management of nutrition impact symptoms (NIS) in advanced cancer. Methods Using a human-centered design framework, NIS management content and personalized rules were designed, and a system prototype was developed. Experts, patients, and family caregivers were invited to participate in a usability evaluation. Usability was assessed via standardized task-based testing and the Post-Study System Usability Questionnaire (PSSUQ), supplemented by semi-structured interviews to collect user experiences and suggestions. Results he system comprised three main modules: self-reporting, personalized recommendation, and interactive feedback. In usability testing, user task completion rate and accuracy both reached 100%, with an average completion time of 374.7(373.0,380.0) seconds. The average PSSUQ score for patients and caregivers was 1.31±0.53, and for experts, it was 1.44±0.54. The users believed the system design reasonable, the content reliable and comprehensive, and felt it met personalized symptom management needs. Suggestions included enhancing guidance prompts and optimizing functionality. Conclusion The NIS personalized information recommendation system is a valuable tool for home-based NIS management in advanced cancer.