Objective To explore the characteristics and population differences in home blood glucose management among pancreatic cancer patients after surgery, to provide guidance for developing blood glucose management or applications for this population. Methods A descriptive qualitative study was designed. Seventeen pancreatic cancer patients after surgery were purposively recruited to participate in semi-structured interviews. Content analysis was conducted to analyze the interview data, which involved the manual extraction of salient themes and characteristics pertaining to postoperative blood glucose management. The resultant patient profiles were visualized using word clouds and summary tables. Results User profile tags on home blood glucose management in pancreatic cancer patients after surgery were characterized by six dimensions: awareness, dietary adjustment, exercise rehabilitation, medication adherence, mental health status, and medical resource support. The user profile consisted in four types:proactive management, excessive control, passive dependency, and resource-constrained. Conclusion Pronounced disparities in know-ledge and practice regarding home blood glucose management exist among pancreatic cancer patients after surgery. Therefore, the development of any intervention program or digital health platform must be preceded by robust patient profiling to facilitate precision management strategies that are congruent with the characteristics of distinct user groups.