Objective To explore the effectiveness of social prescribing in secondary prevention among patients with osteoporotic fracture, and to provide practical reference for hospital-community integrated health management. Methods One hundred patients with osteoporotic fracture were randomized into two groups, with 50 in each.The control group received routine intervention, while the observation group received individualized social prescribing coordinated by a medical social worker, involving a multidisciplinary team and health volunteers as liaisons, integrating bone health education, follow-up, nutrition, exercise, and community support.Osteoporosis related knowledge, pain, quality of life, social support, and medication adherence in both groups were assessed before the intervention, and at 3-, 6-, and 12-months after the intervention. Results After the intervention, the scores of knowledge and social support in the observation group were significantly higher than those in the control group (group effect, time effect, and interaction effect were all significant; all P＜0.05).The time effect and interaction effect for quality of life and pain were significant (all P＜0.05).There was no statistically significant difference in medication adherence between the two groups (P＞0.05). Conclusion Social prescribing can effectively improve the knowledge level of patients with osteoporotic fracture, help them gain social support, and enhance their quality of life.