Objective To develop a glycemic management protocol for critically ill patients during enteral nutrition and to evaluate its effectiveness. Methods A quasi-experimental study using a historical control group was conducted.A total of 100 patients receiving enteral nutrition were assigned to either a control group (n=50) or an intervention group (n=50) according to their admission period.The control group received routine glycemic management, while the intervention group received an evidence-based glycemic management protocol for critically ill patients.Glycemic control outcomes during enteral nutrition were compared between the two groups. Results No statistically significant differences were observed between the two groups in mean blood glucose levels or the total number of glucose measurements during enteral nutrition (both P＞0.05).However, the intervention group had significantly lower coefficient of variation of blood glucose and incidence of stress-induced hyperglycemia, whereas significantly higher frequency and proportion of blood glucose readings within the target range compared with the control group (all P＜0.05). Conclusion The evidence-based glycemic management measures for critically ill patients during enteral nutrition can effectively improve glycemic control outcomes.