Objective To develop a multidisciplinary collaborative nursing program for oral cancer patients undergoing free flap transplantation, and to evaluate its implementation effects, with the aim of promoting perioperative recovery. Methods A prospective nonconcurrent controlled study was conducted.Fifty patients admitted from January to June 2024 were assigned to a control group and received routine nursing care; another 50 patients admitted from July to December 2024 were assigned to an intervention group and received a multidisciplinary collaborative nursing program.The nutritional indicators, swallowing function, and quality of life were compared between the 2 groups. Results After the intervention, the serum albumin, hemoglobin, and prealbumin levels of the intervention group were significantly better than those of the control group (all P＜0.05).The intervention, time, and intervention-by-time interaction effects between the two groups were statistically significant in body mass index (BMI), Water Swallowing Test scores, and quality-of-life scores （all P＜0.05）. Conclusion The multidisciplinary collaborative nursing program effectively improves postoperative nutritional status, swallowing function, and quality of life in oral cancer patients undergoing free flap transplantation.